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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT1
All Species:
10.3
Human Site:
S535
Identified Species:
18.89
UniProt:
Q96EB6
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96EB6
NP_001135970.1
747
81681
S535
P
P
T
P
L
H
V
S
E
D
S
S
S
P
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001087854
741
80936
S529
P
P
T
P
L
H
I
S
E
D
S
S
S
P
E
Dog
Lupus familis
XP_546130
745
81496
D533
T
P
L
N
I
S
E
D
S
S
S
P
E
R
T
Cat
Felis silvestris
Mouse
Mus musculus
Q923E4
737
80353
H525
E
L
P
P
T
P
L
H
I
S
E
D
S
S
S
Rat
Rattus norvegicus
Q5RJQ4
350
39301
Q144
R
V
A
G
L
E
P
Q
D
L
V
E
A
H
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508324
480
51688
A274
S
P
P
D
A
L
A
A
P
A
R
P
E
Q
M
Chicken
Gallus gallus
NP_001004767
756
82614
S547
P
P
T
P
L
D
I
S
E
D
S
G
S
P
E
Frog
Xenopus laevis
NP_001091195
710
78684
F497
P
P
R
I
H
K
G
F
L
T
S
P
E
T
I
Zebra Danio
Brachydanio rerio
Q7ZVK3
379
42296
V173
N
I
D
T
L
E
R
V
A
G
L
E
G
E
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477351
823
91818
R571
S
T
F
S
C
G
K
R
S
T
A
A
E
A
A
Honey Bee
Apis mellifera
XP_395386
868
98678
R613
E
E
C
Q
V
F
P
R
I
I
E
I
S
S
E
Nematode Worm
Caenorhab. elegans
Q21921
607
68747
T401
I
M
E
Q
Q
G
K
T
K
S
Q
K
P
S
Q
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53685
503
57684
S297
Q
N
I
D
N
L
E
S
Y
A
G
I
D
P
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
93.3
91.4
N.A.
85.1
23.4
N.A.
49.7
68.1
57.9
22.2
N.A.
37.2
39.9
31.3
N.A.
Protein Similarity:
100
N.A.
95.5
94.3
N.A.
90
33.3
N.A.
54.7
75.4
69.3
35
N.A.
52.2
55.9
47.5
N.A.
P-Site Identity:
100
N.A.
93.3
13.3
N.A.
13.3
6.6
N.A.
6.6
80
20
6.6
N.A.
0
13.3
0
N.A.
P-Site Similarity:
100
N.A.
100
20
N.A.
20
20
N.A.
13.3
86.6
20
13.3
N.A.
13.3
20
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
35.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
8
0
8
8
8
16
8
8
8
8
8
% A
% Cys:
0
0
8
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
16
0
8
0
8
8
24
0
8
8
0
16
% D
% Glu:
16
8
8
0
0
16
16
0
24
0
16
16
31
8
31
% E
% Phe:
0
0
8
0
0
8
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
0
16
8
0
0
8
8
8
8
0
8
% G
% His:
0
0
0
0
8
16
0
8
0
0
0
0
0
8
0
% H
% Ile:
8
8
8
8
8
0
16
0
16
8
0
16
0
0
8
% I
% Lys:
0
0
0
0
0
8
16
0
8
0
0
8
0
0
0
% K
% Leu:
0
8
8
0
39
16
8
0
8
8
8
0
0
0
0
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
8
8
0
8
8
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
31
47
16
31
0
8
16
0
8
0
0
24
8
31
0
% P
% Gln:
8
0
0
16
8
0
0
8
0
0
8
0
0
8
8
% Q
% Arg:
8
0
8
0
0
0
8
16
0
0
8
0
0
8
0
% R
% Ser:
16
0
0
8
0
8
0
31
16
24
39
16
39
24
8
% S
% Thr:
8
8
24
8
8
0
0
8
0
16
0
0
0
8
8
% T
% Val:
0
8
0
0
8
0
8
8
0
0
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _